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It is noteworthy that during the initial phase of functional impairment in certain organs, such as liver injury, kidney injury, and cardiovascular disease, increased intestinal permeability and endotoxin release can be detected, which helps to identify some high-risk adverse events early ( FIGURE 1 Signal transduction pathway, serving as the foundation for various cellular functions such as proliferation, differentiation, apoptosis, metabolism, oxidative stress, and immune response, facilitates the transmission of extracellular signaling molecules to the cell via cell membrane or intracellular receptors